4th Generation Cephalosporins

Cephalosporins (β-Lactams)

AMEG B
Banned in Poultry

Drugs:

• Parenteral:
  • Cefquinome

Gr+ (++++), Gr- (++++)
Antibacterial spectrum:

• Good for everything: Both Gr+ and Gr-
  • BUT ESBL Resistant Bacteria are resistant even to 4th Generation Cephalosporins
• Outstanding efficiency

Pharmacokinetics:
Lipophilic > Extensive Liver metabolism > Avoid in liver failure patients
Mostly Parenteral
Better distribution